It is generally accepted that the thyroid autoantibodies thyroglobulin and thyroid peroxidase reflect disease activity and progression and are valuable in disease prediction and the classification of Hashimoto’s and Graves’ disease.
While clinicians rely on antibody levels and elevations in thyroid stimulating hormone, they give little attention to the factors involved in thyroid autoimmunity. Researchers and clinicians should be asking the question, why does the human body react to its own antigens resulting in the production of potential harmful autoantibodies? This event may be cause by environmental factors such as bacterial or viral infections or toxin haptenic chemicals binding to human tissue, causing modification of self-antigens and the subsequent production of autoantibodies.
How do you know if you have Hashimoto’s disease?
Let’s say hypothyroidism symptoms describe you perfectly. How you know if your hypothyroidism is due to Hashimoto’s disease? Although a positive serum antibody test is the definitive test, it’s good to be aware of some classic symptoms and scenarios that typically go along with the condition. Most cases of Hashimoto’s unfold as a gradual attack of the immune system against the thyroid, with TSH levels and symptoms of hyperthyroidism slowly escalating. While the person may have normal TSH levels thanks to a thyroid hormone medication, the underlying problem of immune dysregulation goes untreated, as do their symptoms.
• feeling tired or sluggish
• feeling cold – hands, feet, all over
• require excessive amounts of sleep to function well
• weight gain despite following various diets
• difficult, infrequent bowel movements
• depression and lack of motivation
• morning headaches that wear off as the day progresses
• thinning of hair on scalp or excessive hair loss
• dryness of skin
• mental sluggishness