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Isocort & Glandulars

A list of products used to treat adrenal fatigue :

Isocort, Ashwagandha, Rhodiola, Zinc, Glandulars, Phosphatidyl Serine.

Isocort and Glandulars would be used to treat mild cases of Adrenal Fatigue although the adrenals may not respond to these and, therefore, HC may be needed.

Isocort is a Freeze dried Adrenal Cortex (Soluble Fractionation), Echinacea Extract, Prunus spp. and Lomatium Dissectum Root Isolate (Kreb Concentrate-2%). It may contain 1.5 mg of cortisol. Some have trouble with Isocort due to the Echinacea as it belongs to the ragweed family. Isocort may be purchased over the internet and is available at many different sites.

Ashwagandha In Ayurveda ashwagandha is considered a rasayana herb. This herb is also considered an adaptogen which is an herb that works to normalize physiological function, working on the HPA axis and the neuroendocrine system. Ashwagandha has many beneficial elements, including flavonoids and members of the withanolide class. Numerous modern studies have found that ashwagandha shows great promise for being effective in reducing inflammation, decreasing stress, increasing mental activity, invigorating the body, and as an antioxidant. Ashwagandha will help to balance your high and low cortisol levels with its activity that is similar to GABA, which explains why the plant is effective in reducing anxiety.

Rhodiola or Rhodiola Rosea may be effective for improving mood and alleviating depression. Pilot studies on human subjects showed that it improves physical and mental performance, and may reduce fatigue. Rhodiola rosea’s effects potentially are related to optimizing serotonin and dopamine levels due to monoamine oxidase inhibition and its influence on opioid peptides such as beta-endorphins, although these specific neurochemical mechanisms have not been clearly documented with scientific studies. Rhodiola is included among a class of plant derivatives called adaptogens which differ from chemical stimulants, such as nicotine, and do not have the same physiological effects. In Russia and Scandinavia, Rhodiola rosea has been used for centuries to cope with the cold Siberian climate and stressful life. Such effects were provided with evidence in laboratory models of stress using the nematode C. elegans, and in rats in which Rhodiola effectively prevented stress-induced changes in appetite, physical activity, weight gain and the estrus cycle.

Holy Basil (or Tulsi) is used to lower high cortisol it is regarded as an ‘adaptogen’ or anti-stress agent. Recent studies have shown that the leaves afford significant protection against stress. It purifies blood and helps prevent several common ailments. Holy Basil is not the same kind of basil that you grow in your back yard.

Phosphatidyl Serine (PS) is used to lower high cortisol. It has a very calming effect and is best used 2 4 hours before bed time.

Zinc is used to lower high cortisol and works well when taken with PS.

DHEA will lower cortisol if you already have low DHEA, so it can be used in those with high cortisol. We do not recommend supplementing with DHEA until adrenals are fully supported or healed.

Most glandular products contain a combination of herbs and are not recommended. Glandulars in most cases contain the whole adrenal gland and therefore contain adrenaline. Products containing a combination of herbs usually contain some for both high and low cortisol and are counterproductive.


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