This website is dedicated to the millions of thyroid patients who are being ignored and left to suffer unnecessarily, and to healthcare practitioners, who want to better serve those patients.

References to TPA Rebuttal to the Scottish Governments Submission (Thyroid Petition)

  • Barnes, B MD, Hypothyroidism: The Unsuspected Illness, Harper & Row, 1976 (Although exaggerated by many, Dr. Barnes did not claim that low body temperature was a unique symptom of hypothyroidism.)
  • Chan V, Landon J. Urinary thyroxine excretion as index of thyroid function. Lancet. 1972, (Jan 1) 7740: 4-6
  • Tal E , Sulman FG. Urinary thyroxine. Lancet. 1972, 1291
  • Chan V, Besser GM, Landon J, Ekins RP. Urinary triiodothyronine excretion as index of thyroid function. Lancet 1972, (Aug 5) 253-256
  • Chan V, Besser GM, Landon J. Effects of oestrogen on urinary thyroxine excretion. Br Med J. 1972, 4: 699-701
  • Rastogi GK, Sawhney, Sinha, Thomas, Devi. Serum and urinary levels of thyroid hormones in normal pregnancy. Obstet Gynecol. 1974, 2: 176-80
  • Godowsky P,Siersbaek-Nielsen K, Mlholm Hansen J. Urinary excretion of thyroxine in different thyroid states. Acta Endocrinol (Kopenh). 1978, 87: 525-3
  • Kolendorf K, Broch Mller B, Rogowski P. The influence of chronic renal failure on serum and urinary thyroid hormone levels. Acta Endocrinol (Kopenh). 1978, 89: 80-8
  • Ali Afrasiaki M, Dabir Vaziri N, Grant Gwinup, Mays M, Barton CH, Ness RL,Valenta LJ. Thyroid function in the nephrotic syndrome. Ann Int Med. 1979, 90, 335-8
  • Aizawa T, Yamada T, Tawata M, Shimizu T, Furuta S, Kiyosawa K, Yakata M. Thyroid hormone metabolism in patients with liver cirrhosis, as judged by urnary excretion of triiodothyronine. J Am Geriatrics Soc. 1980;28(11):485-91
  • Yoshida K, Sakurada T, Kaise K, Saito S, Yoshinaga K. Measurement of triiodothyronine in urine. Tohoku J Exp Med. 1980;132(4):389-95
  • Lopresti JS, Warren DW, Kaptein EM, Croxson MS, Nicoloff JT. Urinary immunoprecipitation method for estimation of thyroxine to triiodothyronine conversion in altered thyroid states. J Clin Endocrinol Metab. 1982;55( 4):666-70
  • Yoshida K, Sakurada T, Kaise K, Yamamoto M, Saito S, Yoshinaga K. Thyroid stimulation test with urinary T3 concentration as an index of thyroid response. Tohuku J Exp Med. 1983;139(3):271-7
  • Mirralles-Garcia JM, Mories-Alvarez MT, Reglero-Chillon A, Lanao JM, Corrales-Hernandez JJ, Garcia-Diez LC. Urinary kinetics of triiodothyronine and their modification with age. Horm Metab Res. 1985;17(7):366-9
  • Orden I, Pie, Juste, Marsella, Blasco. Thyroxine in unextracted urine. Acta Endocrinol (Kopenh). 1987;114:503-8
  • Faber J, Siersbaek-Nielsen K, Kirkegaard C. Renal handling of thyroxine, 3,5,3- and 3,3,5-triiodothyronine, 3,3-diiodothyronine in man. Acta Endocrinol (Kopenh). 1987;115:144-8
  • Orden I, Pie J, Juste MG, Giner A, Gomez ME, Escanero JF. Urinary triiodothyronine excretion. Rev Espan Fisiol. 1988;44 (2):179-84
  • Hertoghe J. The usefulness of evaluating the urinary excretion of triiodothyronine and thyroxine in the urines of 24 hours for diagnosis of thyroid dysfunction and follow-up of thyroid treatment. Conference in Antwerp, Belgium, March 1975
  • Baisier WV, Hertoghe J, Eeckhaut W. Thyroid insufficiency. Is TSH the only diagnostic tool? J Nutr Env Med. 2000; 10: 105-13
  • Baisier WV, Hertoghe J, Eeckhaut W. Thyroid insufficiency. Is thyroxine the only valuale drug? J Nutr Env Med. 2001;11:159-166
  • Hertoghe T. The efficacy of diagnosing borderline and overt hypothyroidism with the laboratory assessment of triiodothyronine and thyroxine excretion in the urines of 24 hours. A comparison with plasma thyroid tests. Optimal hormone therapy in the aging adult. Basic and advanced seminar, San Francisco, February, 2000
  • Wilson James L. Adrenal Fatigue, The 21st Century Stress Syndrome. Smart Publications. ISBN 1-890572-15-2
  • Dillman E, Gale C, Green W, et al. Hypothermia in iron deficiency due to altered triiodithyroidine metabolism. Regulatory, Integrative and Comparative Physiology 1980;239(5):377-R381.
  • Smith SM, Johnson PE, Lukaski HC. In vitro hepatic thyroid hormone deiodination in iron-deficient rats: effect of dietary fat. Life Sci 1993;53(8):603-9.
  • Zimmermann MB, Khrle J. The Impact of Iron and Selenium Deficiencies on Iodine and Thyroid Metabolism: Biochemistry and Relevance to Public Health. Thyroid 2002;12(10): 867-78.
  • Jabbar A, Yawar A, Waseem S, Islam N, Ul Haque N, Zuberi L, Khan A, Akhter J. Vitamin B12 deficiency common in primary hypothyroidism. Department of Medicine, Aga Khan University, Karachi, Pakistan. 2008 May;58(5):258-61.
  • Julia Brsony, P. Lakatos, J. Fldes and T. Fehr. Effect of vitamin D3 loading and thyroid hormone replacement therapy on the decreased serum 25-hydroxyvitamin D level in patients with hypothyroidism: Acta Endocrinol November 1, 1986 113 329-334
  • B. CATARGI, F. PARROT-ROULAUD, C. COCHET, D. DUCASSOU, P. ROGER, and A. TABARIN. Thyroid. December 1999, 9(12): 1163-1166. doi:10.1089/thy.1999.9.1163. Published in Volume: 9 Issue 12: January 30, 2009
  • Bjrn G. Nedreb, Ottar Nygrd, Per M. Ueland, and Ernst A. Lien; Plasma Total Homocysteine in Hyper- and Hypothyroid Patients before and during 12 Months of Treatment. Clinical Chemistry September 2001 vol. 47 no. 9 1738-1741
  • JOHN E. JONESt PAUL C. DESPER, STANLEY R. SHANE, AND EDMUND B. FLINK .Magnesium Metabolism in Hyperthyroidism and Hypothyroidism: Journal of Clinical Investigation. Vol. 45, No. 6, 1966
  • Lawrence Wilson, MD .COPPER TOXICITY SYNDROME Revised, July 2011, The Center For Development. http://www.drlwilson.com/articles/copper_toxicity_syndrome.htm
  • Vivek R Joshi, Ayaz K Mallick, Manjunatha Goud B K, Ravindra Maradi, Maheshwar G Reddy, Raghavendra Tey, Gaurav Shorey. Effect of serum copper concentration and ceruloplasmin on lipid parameters leading to increased propensity to cardiovascular risk. Department of Biochemistry, Melaka Manipal Medical College, Manipal University. ISSN: 0975-8585Iham Amir Al-Juboori , Rafi Al-Rawi, Hussein Kadhem A-Hakeim. Estimation of Serum Copper, Manganese, Selenium, and Zinc in Hypothyroidism Patients. IUFS Journal of Biology Short Communication 121 IUFS J Biol 2009, 68(2): 121-126
  • Rajagopal KR, Abbrecht PH, Derderian SS, Pickett C, Hofeldt F, Tellis CJ, Zwillich CW. Obstructive sleep apnea syndrome and hypothyroidism (a report of three cases)].Ann Intern Med. 1984 Oct; 101(4):491-4.
  • Rack SK, Makela EH. Hypothyroidism and depression: a therapeutic challenge Department of Behavioural Medicine and Psychiatry. Ann Pharmacother 2000 Oct; 34(10):1142-
  • Jonathan Stephen Murray, Rubaraj Jayarajasingh, Petros Perros. Deterioration of symptoms after start of thyroid hormone replacementBMJ.2001 August 11; 323(7308):332-333
  • Annane D, Sbille V, Charpentier C, Bollaert PE, Franois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troch G, Chaumet-Riffaud P, Bellissant E.Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002 Aug 21;288(7):862-71.
  • C.Orian Truss, M.D. Restoration of Immunologic Competence to Candida Albicans [http://orthomolecular.org/library/jom/1980/pdf/1980-v09n04-p287.pdf]
  • Diabetes Care January 2011 vol. 34 no. Supplement 1 S11-S61
  • McDermott JH, Coss A, Walsh CH. Celiac disease presenting as resistant hypothyroidism. Thyroid. 2005 Apr;15(4):386-8.
  • Grozinsky-Glasberg S, Fraser A, Nahshoni E, Weizman A, Leibovici L., Thyroxine-Triiodothyronine Combination Therapy Versus Thyroxine Monotherapy for Clinical Hypothyroidism: Meta-Analysis of Randomized Controlled Trials, J Clin Endocrin Metab, 2006, 91(7): 2592-2599
  • Joffe RT, Brimacombe M, Levitt AJ, Stagnaro-Green A, Treatment of Clinical Hypothyroidism with Thyroxine and Triiodothyronine: A Literature Review and Meta-analysis, Psychomatics 2007; 48:379-38
  • Escobar-Morreale H, Botella-Carretero JI, Escobar del Rey F, Morreale de Escobar G, REVIEW: Treatment of Hypothyroidism with Combinations of Levothyroxine plus Liothyronine, J Clin Endocrinol Met, 2005, 90(8):4946-4954
  • Saravanan P, Chau F, Roberts N, Vedhara K, Greenwood R, Dayan CM, 2002, Psychological Well-Being in Patients on “Adequate” Doses of L-Thyroxine Results of a Large, Controlled Community-Based Questionnaire Study, Clinical Endocrinology, 2002, 57: 577-585
  • Krantz JC Jr., New Drugs and the Kefauver-Harris Amendment, J New Drugs, 1966, Mar-Apr;6(22):77-9
  • Krantz JC Jr., The Kefauver-Harris amendment after sixteen years, Mil Med. 1978 Dec;143(12):883.
  • Krenning, E.P., Docter, R., Visser, T.J., et al.: Replacement therapy with L-thyroxine: serum thyroid hormone and thyrotropin levels in hypothyroid patients changing from desiccated thyroid to pure thyroxine substitution therapy. Neth. J. Med., 28(1):1-5, 1981.
  • Singh, S.P., Feldman, E.B., and Carter, A.C.: Desiccated thyroid and levothyroxine in hypothyroidism: comparison in replacement therapy. N.Y. State J. Med., 72(9):1045-1048, 1972.
  • Sawin, C.T., Hershman, J.M., Fernandez-Garcia, R., et al.: A comparison of thyroxine and desiccated thyroid in patients with primary hypothyroidism. Metabolism, 27(10):1518-1525, 1978.
  • LeBoff, M.S., Kaplan, M.M., Silva, J.E., et al.: Bioavailability of thyroid hormones from oral replacement preparations. Metabolism, 31(9):900-905, 1982.
  • Lavietes, P.H.. and Epstein, F.H.: Thyroid therapy of myxedema: A comparison of various agents with a note on the composition of thyroid secretion in man. Ann. Intern. Med., 60:79-87, 1964.
  • Gorowski, T., Pucilowska, J., and Wernic, K.: Comparative effects of desiccated thyroid gland and sodium salt of L-thyroxine in the treatment of hypothyroidism.Pol. Tyg. Lek., 44(32-33):768-770, 1989.
  • Felt, V. and Nedvidkova, J.: Comparison of treatment with L-thyroxine and a dried thyroidgland preparation in patients with hypothyroidism. Vnitr. Lek., 28 (11):1067-1073, 1982
  • Wartofsky, L.: Combined levotriiodothyronine and levothyroxine therapy for hypothyroidism: are we a step closer to the magic formula? Thyroid, 14(4):247- 248, 2004
  • Kosowicz, J., Horst-Sikorska, W., Lacka, K., et al.: Outcome of treating hypothyroidism with thyreoideum. Pol. Tyg. Lek, 48(27-28):599-602, 1993.
  • Warszawie, C.M.K.P.: Treatment of hypothyroidism with L-thyroxine. Pol. Tyg. Lek, 48(27-28):605-608, 1993.
  • McGavack, T.H. and Reckendorf, H.K.: Therapeutic activity of desiccated thyroid substance, sodium Lthyroxine and D, L-triiodothyronine: a comparative study. Am. J. Med., 20:774-777, 1956
  • Baisier, W.V., Hertoghe, J., and Eeckhaut, W.:Thyroidinsufficiency: is thyroxine the only valuable Drug? J. Nutr. Environ. Med., 11:159-166, 2001.
  • Gautam Das, Shweta Anand & Parijat De. Does synthetic thyroid extract work for everybody? Endocrine Abstracts (2007) P316
  • Alan R. Gaby, MD. Sub-laboratory Hypothyroidism and the Empirical use of Armour Thyroid. (Altern Med Rev 2004;9(2):157-179)
  • Lowe, J.C.: Natural desiccated thyroid: Guttlers false claim about It. Thyroid Science 4(9):C1-6, 2009
  • Novak, Edmund A. M.D.; Holthaus, Joseph M. M.D.; Ogborn, Richard O. M.D: Clinical Study of Levo-Thyroxine and Aged Desiccated Thyroid in Euthyroid Subjects: American Journal of the Medical Sciences: March 1964
  • Alan R. Gaby, MD. Sub-laboratory Hypothyroidism and the Empirical use of Armour Thyroid. (Altern Med Rev 2004;9(2):157-179)
  • Thompson, W.O., McLellan, L.L., Thompson, P.K., et al.: The rates of utilization of thyroxine and of desiccated thyroid in man: the relation between the iodine in desiccated thyroid and thyroxine. Arch. Intern. Med., 1932.
  • Boothby, W. M., Sandiford, I., Sandiford, K., et al.: Abstract of Communication to the XIIth International Physiol. Congress held at Stockholm, Aug. 3-6, 1926. Skandinav. Archiv. 1926, xlix, 99. Metabolism studies showing the effect of desiccated thyroid and thyroxin on a patient with myxedema.
  • Thompson, W.O., Nadler, S.B., Taylor, S. G., III, and Thompson, P. K.: The calorigenic action of various thyroid derivatives. J. Clin. Invest. (Proc.), 13:690, 1934.
  • Foster, G. L., Palmer, W. W., and Leland, J. P.: A comparison of the calorigenic potencies of l-thyroxine, dl-thyroxine, and thyroid gland, with a note on the thyroxine content of the acid-soluble fraction of the peptic digest of thyroid protein. J. Biol. Chem., 115:467, 1936
  • Thompson, W. O., Thompson, P. K., Brailey, A. G., et al.: The calorigenetic action of thyroxin at different levels of basal metabolism in myxedema. J. Clin. Invest., 7(3): 437463, 1929.
  • Sturnick, M.I. and Falcon-Lesses, M.: A comparison of the effect of desiccated thyroid and sodium levothyroxine on the serum protein-bound iodine. New Engl. J. Med., 264:609, 1961.
  • Sisson, J.C.: Principles of, and pitfalls in, thyroid function tests. J. Nuclear Med., 6:853-901, 1965.
  • Robertson, J.D. and Kirkpatrick, H.F.W.: Changes in basal metabolism, serum protein-bound iodine and cholesterol during treatment of hypothyroidism with oral thyroid and l-thyroxine sodium. Brit. Med. J., March 22, 1:624, 1952.
  • Gilman, A.G. and Murad, F.: Thyroid and antithyroid drugs. In The Pharmacologic Basis of Therapeutics, (ed 5). Edited by L.S. Goodman and a. Gilman, New York, MacMilIan, 1975, p.1398.
  • Means, J.H., DeGroot, L.J., and Stanbury, J.B.: The Thyroid and Its Diseases, 3rd edition. New York, McGraw-Hill, 1963, p. 334.
  • Werner, S.C.: Treatment of hypothyroidism. In The Thyroid, 3rd edition. Edited by S.C. Werner and S.H. Ingbar, New York, Harper and Row, 1971, p.834.
  • Daughaday, W.H.: The adenohypophysis. In Textbook of Endocrinology, 5th edition. Edited by R.H. Williams, Philadelphia, Saunders, 1974, p.60.
  • Lowe, J.C.: Stability, effectiveness, and safety of desiccated thyroid vs levothyroxine: rebuttal to the British Thyroid Association. Thyroid Science, 4(3):C-1-12, 2009.
  • Novak, Edmund A. M.D.; Holthaus, Joseph M. M.D.; Ogborn, Richard O. M.D: Clinical Study of Levo-Thyroxine and Aged Desiccated Thyroid in Euthyroid Subjects: American Journal of the Medical Sciences: March 1964
  • Frederick L. Benoit.ieutenant Commander, MC, MC, USN: Treatment of Riedel’s Thyroiditis With Desiccated Thyroid.Endocrine Clinic and Medical Service, U.S. Naval Hospital,Oakland..Submitted July 14, 1964.
  • Beverley Strisower, A.B.,John W Gofman, MD., Elmer Galioni, MD.,Joshua H Rubinger, M.D.,Georgfe W OBrien M.D. and Alexander Simon, M.D. Effect of Long-Term Administration of Desiccated Thyroid on Serum Lipoprotein and Cholesterol Levels.The Journal of Clinical Endocrinology & Metabolism January 1, 1955 vol. 15 no. 1 73-80
  • George S. Serif and Alan K Brevik.: “ Effects of Butyl-4-hydroxy-3,5-diiodobenzoate on the Conversion of p-carotene to Vitamin A in the Rat.” The Journal of Biological Chemistry. Vol. 235, No. 8, August 1960
  • McGavack, T. R. and Reckendorf, H. K.: Therapeutic activity of desiccated thyroid substance, sodium Ithyroxine and d,1 triiodothyronine: A comparative study. Amer. J. Med., 20: 774, 1956.
  • Singh, S.P., Feldman, E.B., and Carter, A.C.: Desiccated thyroid and levothyroxine in hypothyroidism: comparison in replacement therapy. N.Y. State J. Med., 72(9):1045-1048, 1972.
  • Lavietes, P.H. and Epstein, F.H.: Thyroid therapy of myxedema: A comparison of various agents with a note on the composition of thyroid secretion in man. Ann. Intern. Med., 60:79-87, 1964.
  • Haynes, R.C., Jr.: Thyroid and antithyroid drugs. In Goodman and Gilmans The Pharmacological Basis of Therapeutics, 8th edition. New York, Perg
  • Jabbar A, Yawar A, Waseem S, Islam N, Ul Haque N, Zuberi L, Khan A, Akhter J. Vitamin B12 deficiency common in primary hypothyroidism. Department of Medicine, Aga Khan University, Karachi, Pakistan. 2008 May;58(5):258-61
  • Ness-Abrahamof R, Nabriski DA, Braverman LE, Shilo L, Weiss E, Reshef T, Shapiro MS, ShenkmanL..Prevalence and evaluation of B12 deficiency in patients with autoimmune thyroid disease. Am.J Med Sci. 2006 Sep;332(3):119-22.
  • Julia Brsony, P. Lakatos, J. Fldes and T. Fehr. Effect of vitamin D3 loading and thyroid hormone replacement therapy on the decreased serum 25-hydroxyvitamin D level in patients with hypothyroidism: Acta Endocrinol November 1, 1986 113 329-334
  • Goldberg M, The Case For Euthyroid Hypometabolism, Am J Med Sc October, 1960 pgs 479-493
  • Goldberg M, Dagnosis of Euthyroid Hypometabolism, Am J Obst & Gynec, 81(5): 1053-1058, 1961
  • Jenicek M, Hitchcock DL, Evidence-Based Medicine: Logic and Critical Thinking in Medicine, American Medical Association, 2005, pg 54
  • The UK Guidelines for the Use of Thyroid Function Tests British Thyroid Association of Clinical Biochemists, British Thyroid Foundation, July 2006. http://www.british-thyroid association.org/TFT_guideline_final_version_July_2006.pdf
  • The Royal College of Physicians, The Diagnosis and Management of Primary Hypothyroidism, November 2008, Endorsed by the Royal College of General Practitioners made on behalf of numerous endocrinology associations
  • Thyroid Patient Advocacy. www.tpauk.com
  • Thyroid-UK. www.thyroiduk.org.uk
  • http://www.justice.gov/archive/dag/pubdoc/hcfacreport2010.pdf

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