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Thyroid Acropachy


Acropachy or thyroid acropachy refers to a dermopathy associated with Graves’ disease.[1] It is characterized by soft-tissue swelling of the hands and clubbing of the fingers. Radiographic imaging of affected extremities typically demonstrates periostitis, most commonly the metacarpal bones. The exact cause is unknown, but it is thought to be caused by stimulating auto-antibodies that are implicated in the pathophysiology of Graves thyrotoxicosis. There is no effective treatment for acropachy. Since it is closely associated with Graves disease, it is associated with other manifestations of Graves disease, such as Graves ophthalmopathy[2] and thyroid dermopathy.[3] Hereditary acropachy (also known as “isolated congenital nail clubbing”) may be associated with HPGD.[4] See also

Periosteal reaction Thyroid acropachy

References 1. Jump up ^ Graf, Gratton (2013). Imboden, Hellmann, Stone, ed. Chapter 55. Endocrine & Metabolic Disorders. In: CURRENT Rheumatology Diagnosis & Treatment, 3e. New York, NY: McGraw-Hill. 2. Jump up ^Fatourechi V, Bartley GB, Eghbali-Fatourechi GZ, Powell CC, Ahmed DD, Garrity JA (December 2003). “Graves’ dermopathy and acropachy are markers of severe Graves’ ophthalmopathy”. Thyroid 13 (12): 1141–4. doi:10.1089/10507250360731541. PMID14751035. 3. Jump up ^Fatourechi V, Ahmed DD, Schwartz KM (December 2002). “Thyroid acropachy: report of 40 patients treated at a single institution in a 26-year period”. J. Clin. Endocrinol. Metab. 87 (12): 5435–41. doi:10.1210/jc.2002-020746. PMID12466333. 4. Jump up ^Tariq M, Azeem Z, Ali G, Chishti MS, Ahmad W (January 2009). “Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC)”. J. Med. Genet. 46 (1): 14–20. doi:10.1136/jmg.2008.061234. PMID18805827.

See Pictures of Acropachy HERE


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