..

The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation

Background:
The aim of this study was to discern whether a relation between biochemical parameters, sonography and musculoskeletal data exists in cases of hyperthyroidism and whether they are modifiable through supplementation with selenomethionine and magnesium citrate as well as by acupuncture and manual medicine methods.

Results:
A direct correlation between whole blood selenium and serum magnesium was found in subjects without thyroid disease and in menopausal women, while it was reversed in cases of thyroid diseases as well as in patients with depression, infection, and in infertile women.

Vascularization indices were elevated in cases of newly diagnosed benign thyroid diseases. Musculoskeletal changes i.e. lateral tension and idiopathic moving toes, as well as situations of physical and psychological stress and minor trauma and infection led to an increase of vascularization.

Magnesium levels correlated negatively with these two conditions. The supplementation brought a reduction of the vascularization indices and reduced the incidence of idiopathic moving toes. Treatment of lateral tension required manual medicine methods and acupuncture (gastrocnemius).

A small subgroup of patients showed a further reduction of hyper-vascularization after receiving coenzyme Q10.

Conclusions:
We interpret the elevated thyroid vascularization and low magnesium levels as signs of an inflammatory process related to the musculoskeletal changes. Improvement of thyroid function and morphology can be achieved after correcting the influence of stressors together with the supplementation regime.

We hypothesize that the central biochemical event in thyroid disease is that of an acquired, altered mitochondrial function due to deficiency of:-
magnesium, selenium, and coenzyme Q10.

Moncayo, Roy; Moncayo, Helga

10.1016/j.bbacli.2014.11.002

http://www.sciencedirect.com/science/article/pii/S2214647414000282

see also:
http://dx.doi.org/10.2307/1538196